AustralieFrV1, Main, Exploration, bibRecord, 008E28

Coexistence of Foam Cells and Hypocholesterolemia in Mice Lacking the ABC Transporters Al and G1

Identifieur interne : 008E28 ( Main/Exploration ); précédent : 008E27; suivant : 008E29

Coexistence of Foam Cells and Hypocholesterolemia in Mice Lacking the ABC Transporters Al and G1

Auteurs : Ruud Out [Pays-Bas] ; Wendy Jessup [Australie] ; Wilfried Le Goff [France] ; Menno Hoekstra [Pays-Bas] ; Ingrid C. Gelissen [Australie] ; YING ZHAO [Pays-Bas] ; Léonard Kritharides [Australie] ; Giovanna Chimini [France] ; Johan Kuiper [Pays-Bas] ; M. John Chapman [France] ; Thierry Huby [France] ; Theo J. C. Van Berkel [Pays-Bas] ; Miranda Van Eck [Pays-Bas]

Source :

Circulation research [ 0009-7330 ] ; 2008.

RBID : Pascal:08-0091348

Descripteurs français

Pascal (Inist)
- Coexistence, Transporteur ABC, Cholestérol, Transport biologique, Macrophage, Appareil circulatoire, Mammalia, Hypocholestérolémie, Lipide, Souris.

English descriptors

KwdEn :
- ABC transporter, Biological transport, Cholesterol, Circulatory system, Coexistence, Hypocholesterolemia, Lipids, Macrophage, Mammalia, Mouse.

Abstract

-The concept that macrophages can become foam cells as a result of a disturbed balance between the uptake of cholesterol from lipoproteins and cholesterol efflux is generally accepted. ABCA1 and ABCG1 are two cholesterol transporters that may act sequentially to remove cellular cholesterol, but currently their combined role in vivo is unknown. We report here that targeted disruption of both ABCA1 and ABCG1 in mice, despite severe plasma hypocholesterolemia, leads to massive lipid accumulation and foam cell formation of tissue macrophages. A complete ablation of cellular cholesterol efflux in vitro is observed, whereas in vivo macrophage-specific reverse cholesterol transport to the feces is markedly decreased. Despite the massive foam cell formation of tissue macrophages, no lipid accumulation was observed in the vascular wall, even in mice of 1 year old, indicating that the double knockout mice, possibly because of their hypocholesterolemia, lack the trigger to attract macrophages to the vessel wall. In conclusion, even under hypocholesterolemic conditions macrophages can be converted into foam cells, and ABCA1 and ABCG1 play an essential role in the prevention of foam cell formation.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 003755
to stream PascalFrancis, to step Curation: 002884
to stream PascalFrancis, to step Checkpoint: 003353
to stream Main, to step Merge: 009767
to stream Main, to step Curation: 008E28

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Coexistence of Foam Cells and Hypocholesterolemia in Mice Lacking the ABC Transporters Al and G1</title>
<author><name sortKey="Out, Ruud" sort="Out, Ruud" uniqKey="Out R" first="Ruud" last="Out">Ruud Out</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Biopharmaceutics 9, Leiden/Amsterdam Center for Drug Research, Leiden University</s1>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>Division of Biopharmaceutics 9, Leiden/Amsterdam Center for Drug Research, Leiden University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jessup, Wendy" sort="Jessup, Wendy" uniqKey="Jessup W" first="Wendy" last="Jessup">Wendy Jessup</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Centre for Vascular Research , School of Medical Sciences, University of New South Wales</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Le Goff, Wilfried" sort="Le Goff, Wilfried" uniqKey="Le Goff W" first="Wilfried" last="Le Goff">Wilfried Le Goff</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>INSERM U551</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Université Pierre et Marie Curie-Paris6, UMR S551</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hoekstra, Menno" sort="Hoekstra, Menno" uniqKey="Hoekstra M" first="Menno" last="Hoekstra">Menno Hoekstra</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Biopharmaceutics 9, Leiden/Amsterdam Center for Drug Research, Leiden University</s1>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>Division of Biopharmaceutics 9, Leiden/Amsterdam Center for Drug Research, Leiden University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gelissen, Ingrid C" sort="Gelissen, Ingrid C" uniqKey="Gelissen I" first="Ingrid C." last="Gelissen">Ingrid C. Gelissen</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Centre for Vascular Research , School of Medical Sciences, University of New South Wales</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ying Zhao" sort="Ying Zhao" uniqKey="Ying Zhao" last="Ying Zhao">YING ZHAO</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Biopharmaceutics 9, Leiden/Amsterdam Center for Drug Research, Leiden University</s1>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>Division of Biopharmaceutics 9, Leiden/Amsterdam Center for Drug Research, Leiden University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kritharides, Leonard" sort="Kritharides, Leonard" uniqKey="Kritharides L" first="Léonard" last="Kritharides">Léonard Kritharides</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Centre for Vascular Research , School of Medical Sciences, University of New South Wales</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chimini, Giovanna" sort="Chimini, Giovanna" uniqKey="Chimini G" first="Giovanna" last="Chimini">Giovanna Chimini</name>
<affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Centre d'Immunologie de Marseille Luminy , Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Université de la Méditerranée</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
<settlement type="city">Marseille</settlement>
</placeName>
<orgName type="university">Université de la Méditerranée</orgName>
</affiliation>
</author>
<author><name sortKey="Kuiper, Johan" sort="Kuiper, Johan" uniqKey="Kuiper J" first="Johan" last="Kuiper">Johan Kuiper</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Biopharmaceutics 9, Leiden/Amsterdam Center for Drug Research, Leiden University</s1>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>Division of Biopharmaceutics 9, Leiden/Amsterdam Center for Drug Research, Leiden University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chapman, M John" sort="Chapman, M John" uniqKey="Chapman M" first="M. John" last="Chapman">M. John Chapman</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>INSERM U551</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Université Pierre et Marie Curie-Paris6, UMR S551</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Huby, Thierry" sort="Huby, Thierry" uniqKey="Huby T" first="Thierry" last="Huby">Thierry Huby</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>INSERM U551</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Université Pierre et Marie Curie-Paris6, UMR S551</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Berkel, Theo J C" sort="Van Berkel, Theo J C" uniqKey="Van Berkel T" first="Theo J. C." last="Van Berkel">Theo J. C. Van Berkel</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Biopharmaceutics 9, Leiden/Amsterdam Center for Drug Research, Leiden University</s1>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>Division of Biopharmaceutics 9, Leiden/Amsterdam Center for Drug Research, Leiden University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Eck, Miranda" sort="Van Eck, Miranda" uniqKey="Van Eck M" first="Miranda" last="Van Eck">Miranda Van Eck</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Biopharmaceutics 9, Leiden/Amsterdam Center for Drug Research, Leiden University</s1>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>Division of Biopharmaceutics 9, Leiden/Amsterdam Center for Drug Research, Leiden University</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">08-0091348</idno>
<date when="2008">2008</date>
<idno type="stanalyst">PASCAL 08-0091348 INIST</idno>
<idno type="RBID">Pascal:08-0091348</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">003755</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002884</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">003353</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">003353</idno>
<idno type="wicri:doubleKey">0009-7330:2008:Out R:coexistence:of:foam</idno>
<idno type="wicri:Area/Main/Merge">009767</idno>
<idno type="wicri:Area/Main/Curation">008E28</idno>
<idno type="wicri:Area/Main/Exploration">008E28</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Coexistence of Foam Cells and Hypocholesterolemia in Mice Lacking the ABC Transporters Al and G1</title>
<author><name sortKey="Out, Ruud" sort="Out, Ruud" uniqKey="Out R" first="Ruud" last="Out">Ruud Out</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Biopharmaceutics 9, Leiden/Amsterdam Center for Drug Research, Leiden University</s1>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>Division of Biopharmaceutics 9, Leiden/Amsterdam Center for Drug Research, Leiden University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jessup, Wendy" sort="Jessup, Wendy" uniqKey="Jessup W" first="Wendy" last="Jessup">Wendy Jessup</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Centre for Vascular Research , School of Medical Sciences, University of New South Wales</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Le Goff, Wilfried" sort="Le Goff, Wilfried" uniqKey="Le Goff W" first="Wilfried" last="Le Goff">Wilfried Le Goff</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>INSERM U551</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Université Pierre et Marie Curie-Paris6, UMR S551</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hoekstra, Menno" sort="Hoekstra, Menno" uniqKey="Hoekstra M" first="Menno" last="Hoekstra">Menno Hoekstra</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Biopharmaceutics 9, Leiden/Amsterdam Center for Drug Research, Leiden University</s1>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>Division of Biopharmaceutics 9, Leiden/Amsterdam Center for Drug Research, Leiden University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gelissen, Ingrid C" sort="Gelissen, Ingrid C" uniqKey="Gelissen I" first="Ingrid C." last="Gelissen">Ingrid C. Gelissen</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Centre for Vascular Research , School of Medical Sciences, University of New South Wales</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ying Zhao" sort="Ying Zhao" uniqKey="Ying Zhao" last="Ying Zhao">YING ZHAO</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Biopharmaceutics 9, Leiden/Amsterdam Center for Drug Research, Leiden University</s1>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>Division of Biopharmaceutics 9, Leiden/Amsterdam Center for Drug Research, Leiden University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kritharides, Leonard" sort="Kritharides, Leonard" uniqKey="Kritharides L" first="Léonard" last="Kritharides">Léonard Kritharides</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Centre for Vascular Research , School of Medical Sciences, University of New South Wales</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chimini, Giovanna" sort="Chimini, Giovanna" uniqKey="Chimini G" first="Giovanna" last="Chimini">Giovanna Chimini</name>
<affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Centre d'Immunologie de Marseille Luminy , Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Université de la Méditerranée</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
<settlement type="city">Marseille</settlement>
</placeName>
<orgName type="university">Université de la Méditerranée</orgName>
</affiliation>
</author>
<author><name sortKey="Kuiper, Johan" sort="Kuiper, Johan" uniqKey="Kuiper J" first="Johan" last="Kuiper">Johan Kuiper</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Biopharmaceutics 9, Leiden/Amsterdam Center for Drug Research, Leiden University</s1>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>Division of Biopharmaceutics 9, Leiden/Amsterdam Center for Drug Research, Leiden University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chapman, M John" sort="Chapman, M John" uniqKey="Chapman M" first="M. John" last="Chapman">M. John Chapman</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>INSERM U551</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Université Pierre et Marie Curie-Paris6, UMR S551</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Huby, Thierry" sort="Huby, Thierry" uniqKey="Huby T" first="Thierry" last="Huby">Thierry Huby</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>INSERM U551</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Université Pierre et Marie Curie-Paris6, UMR S551</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Berkel, Theo J C" sort="Van Berkel, Theo J C" uniqKey="Van Berkel T" first="Theo J. C." last="Van Berkel">Theo J. C. Van Berkel</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Biopharmaceutics 9, Leiden/Amsterdam Center for Drug Research, Leiden University</s1>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>Division of Biopharmaceutics 9, Leiden/Amsterdam Center for Drug Research, Leiden University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Eck, Miranda" sort="Van Eck, Miranda" uniqKey="Van Eck M" first="Miranda" last="Van Eck">Miranda Van Eck</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Biopharmaceutics 9, Leiden/Amsterdam Center for Drug Research, Leiden University</s1>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>Division of Biopharmaceutics 9, Leiden/Amsterdam Center for Drug Research, Leiden University</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Circulation research</title>
<title level="j" type="abbreviated">Circ. res.</title>
<idno type="ISSN">0009-7330</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Circulation research</title>
<title level="j" type="abbreviated">Circ. res.</title>
<idno type="ISSN">0009-7330</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ABC transporter</term>
<term>Biological transport</term>
<term>Cholesterol</term>
<term>Circulatory system</term>
<term>Coexistence</term>
<term>Hypocholesterolemia</term>
<term>Lipids</term>
<term>Macrophage</term>
<term>Mammalia</term>
<term>Mouse</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Coexistence</term>
<term>Transporteur ABC</term>
<term>Cholestérol</term>
<term>Transport biologique</term>
<term>Macrophage</term>
<term>Appareil circulatoire</term>
<term>Mammalia</term>
<term>Hypocholestérolémie</term>
<term>Lipide</term>
<term>Souris</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">-The concept that macrophages can become foam cells as a result of a disturbed balance between the uptake of cholesterol from lipoproteins and cholesterol efflux is generally accepted. ABCA1 and ABCG1 are two cholesterol transporters that may act sequentially to remove cellular cholesterol, but currently their combined role in vivo is unknown. We report here that targeted disruption of both ABCA1 and ABCG1 in mice, despite severe plasma hypocholesterolemia, leads to massive lipid accumulation and foam cell formation of tissue macrophages. A complete ablation of cellular cholesterol efflux in vitro is observed, whereas in vivo macrophage-specific reverse cholesterol transport to the feces is markedly decreased. Despite the massive foam cell formation of tissue macrophages, no lipid accumulation was observed in the vascular wall, even in mice of 1 year old, indicating that the double knockout mice, possibly because of their hypocholesterolemia, lack the trigger to attract macrophages to the vessel wall. In conclusion, even under hypocholesterolemic conditions macrophages can be converted into foam cells, and ABCA1 and ABCG1 play an essential role in the prevention of foam cell formation.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
<li>Pays-Bas</li>
</country>
<region><li>Nouvelle-Galles du Sud</li>
<li>Provence-Alpes-Côte d'Azur</li>
<li>Île-de-France</li>
</region>
<settlement><li>Marseille</li>
<li>Paris</li>
<li>Sydney</li>
</settlement>
<orgName><li>Université de la Méditerranée</li>
</orgName>
</list>
<tree><country name="Pays-Bas"><noRegion><name sortKey="Out, Ruud" sort="Out, Ruud" uniqKey="Out R" first="Ruud" last="Out">Ruud Out</name>
</noRegion>
<name sortKey="Hoekstra, Menno" sort="Hoekstra, Menno" uniqKey="Hoekstra M" first="Menno" last="Hoekstra">Menno Hoekstra</name>
<name sortKey="Kuiper, Johan" sort="Kuiper, Johan" uniqKey="Kuiper J" first="Johan" last="Kuiper">Johan Kuiper</name>
<name sortKey="Van Berkel, Theo J C" sort="Van Berkel, Theo J C" uniqKey="Van Berkel T" first="Theo J. C." last="Van Berkel">Theo J. C. Van Berkel</name>
<name sortKey="Van Eck, Miranda" sort="Van Eck, Miranda" uniqKey="Van Eck M" first="Miranda" last="Van Eck">Miranda Van Eck</name>
<name sortKey="Ying Zhao" sort="Ying Zhao" uniqKey="Ying Zhao" last="Ying Zhao">YING ZHAO</name>
</country>
<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Jessup, Wendy" sort="Jessup, Wendy" uniqKey="Jessup W" first="Wendy" last="Jessup">Wendy Jessup</name>
</region>
<name sortKey="Gelissen, Ingrid C" sort="Gelissen, Ingrid C" uniqKey="Gelissen I" first="Ingrid C." last="Gelissen">Ingrid C. Gelissen</name>
<name sortKey="Kritharides, Leonard" sort="Kritharides, Leonard" uniqKey="Kritharides L" first="Léonard" last="Kritharides">Léonard Kritharides</name>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Le Goff, Wilfried" sort="Le Goff, Wilfried" uniqKey="Le Goff W" first="Wilfried" last="Le Goff">Wilfried Le Goff</name>
</region>
<name sortKey="Chapman, M John" sort="Chapman, M John" uniqKey="Chapman M" first="M. John" last="Chapman">M. John Chapman</name>
<name sortKey="Chapman, M John" sort="Chapman, M John" uniqKey="Chapman M" first="M. John" last="Chapman">M. John Chapman</name>
<name sortKey="Chimini, Giovanna" sort="Chimini, Giovanna" uniqKey="Chimini G" first="Giovanna" last="Chimini">Giovanna Chimini</name>
<name sortKey="Huby, Thierry" sort="Huby, Thierry" uniqKey="Huby T" first="Thierry" last="Huby">Thierry Huby</name>
<name sortKey="Huby, Thierry" sort="Huby, Thierry" uniqKey="Huby T" first="Thierry" last="Huby">Thierry Huby</name>
<name sortKey="Le Goff, Wilfried" sort="Le Goff, Wilfried" uniqKey="Le Goff W" first="Wilfried" last="Le Goff">Wilfried Le Goff</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 008E28 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 008E28 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:08-0091348
   |texte=   Coexistence of Foam Cells and Hypocholesterolemia in Mice Lacking the ABC Transporters Al and G1
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les relations entre la France et l'Australie

Coexistence of Foam Cells and Hypocholesterolemia in Mice Lacking the ABC Transporters Al and G1

Coexistence of Foam Cells and Hypocholesterolemia in Mice Lacking the ABC Transporters Al and G1

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri